Centre for Arctic Health and Molecular Epidemiology

 Department of public health Centre for Arctic Health Publications

Publications

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Mølhave L, Sigsgaard T, Kjærgaard SK, Juto JE, Ukendt KA, Stridh G et al. Study DORES: Dose-response relations for health effects caused by airborne office dust: Research reports from the Air Pollution Unit. Aarhus University, 2007. 54 p.
Long M. The potential of environmental chemicals to affect the aryl hydrocarbon receptor: A molecular and cellular study in vitro and ex vivo. 2007.
Krüger T, Hjelmborg PS, Jönsson BAG, Hagmar L, Giwercman A, Manicardi GC et al. Xenoandrogenic activity in serum differs across European and Inuit populations. Environmental Health Perspectives. 2007;115(Suppl. 1):21-27. doi: 10.1289/ehp.9353
Krüger T, Spano M, Long M, Eleuteri P, Rescia M, Hjelmborg PS et al. Xenobiotic activity in serum and sperm chromatin integrity in European and inuit populations. Molecular Reproduction and Development. 2007. doi: 10.1002/mrd.20747
Elzanaty S, Rignell-Hydbom A, Jönsson BAG, Pedersen HS, Ludwicki JK, Shevets M et al. Association between exposure to persistent organohalogen pollutants and epididymal and accessory sex gland function: Multicentre study in Inuit and European populations. Reproductive Toxicology. 2006;22(4):765-773. doi: 10.1016/j.reprotox.2006.07.005
Mølhave L, Sigsgaard T, Kjærgaard SK, Juto JE, Andersson K, Stridh G et al. Changes in airway mucosal membranes after experimental exposures to dust containing glucan and volatile organic compounds. Exposure characterization. Final summary report to Formas. Aarhus: The Air Pollution Unit, Dept. Occupational and Environmental Medicine, The University of Aarhus., 2006. 10 p.
Long M, Andersen BS, Lindh CH, Hagmar L, Giwercman A, Manicardi GC et al.. Dioxin-like activities in serum across European and Inuit population. 2006. Poster session presented at Dioxin 2006, Oslo, Norway.
Long M, Andersen BS, Lindh CH, Hagmar L, Giwercman A, Manicardi GC et al. Dioxin-like activities in serum across European and Inuit populations. Environmental Health: A Global Access Science Source. 2006;(5):14-26.
Waring R, Bonefeld-Jørgensen EC, Behl C, Loos U, Fickova M, Ramden D. ENDOMET,  Dysregulation of endogenous steroid metabolism potentially alters neuronal and reproductive system development: effects of environmental plasticisers: EU project QLRT-2002-02637 (  01/01/03 - 30/06/06). In   Dysregulation of endogenous steroid metabolism potentially alters neuronal and reproductive system development: effects of environmental plasticisers. 2006. p. 1-84
Andersen HR, Bonefeld-Jørgensen EC, Nielsen F, Jarfeldt K, Jayatissa MN, Vinggaard AM. Estrogenic effects in vitro and in vivo of the fungicide fenarimol. Toxicology Letters. 2006;163(2):142-52. doi: 10.1016/j.toxlet.2005.10.004
AM V, Andersen HR, Bonefeld-Jørgensen EC, Birkhøj Kjærstad M, Nellemann C, Hass U et al. Hvad sker der når mennesker udsættes for en cocktail af hormonforstyrrende pesticider? Miljø og sundhed. 2006;13-19.
Tiido T, Rignell-Hydbom A, Jönsson BAG, Giwercman YL, Pedersen HS, Wojtyniak B et al. Impact of PBC and p,p´-DDE contaminants on human sperm Y:X chromosome ratio: studies in three European populations and the Inuit population in Greenland. Environmental Health Perspectives. 2006;114(5):718-24.
Bonde JP, Toft G, Rylander L, Rigell-Hydbom A, Giwercman A, Spano M et al. Inuendo; Final project report to the EU Commision. 2006.
Vinggaard AM, Hass U, Dalgaard M, Andersen HR, Bonefeld-Jørgensen EC, Christiansen S et al. Prochloraz: an imidazole fungicide with multiple mechanisms of action. International Journal of Andrology. 2006;29(1):186-192. doi: 10.1111/j.1365-2605.2005.00604.x
Stronati A, Manicardi GC, Cecati M, Bordicchia M, Ferrante L, Spanò M et al. Relationships between sperm DNA fragmentation, sperm apoptotic markers and serum levels of CB-153 and p,p'-DDE in European and Inuit populations. Reproduction. 2006;132(6):949-958. doi: 10.1530/rep.1.01034
Giwercman A, Rignell-Hydbom A, Toft G, Rylander L, Hagmar L, Lindh C et al. Reproductive hormone levels in men exposed to persistent organohalogen pollutants: A study of inuit and three European cohorts. Environmental Health Perspectives. 2006 Sept 1;114(9):1348-1353. doi: 10.1289/ehp.8935
Toft G, Rignell-Hydbom A, Tyrkiel E, Shvets MN, Giwercman A, Lindh CH et al. Semen quality and exposure to persistent organochlorine pollutants. Epidemiology. 2006;17(4):450-458.
Hjelmborg PS, Ghisari M, Bonefeld-Jørgensen E. SPE-HPLC purification of endocrine disrupting compounds from human serum for assessment of xenoestrogenic activity. Analytical and Bioanalytical Chemistry. 2006;385(5):875 - 887. doi: 10.1007/s00216-006-0463-9
Bønløkke JH, Stridh G, Sigsgaard T, Kjærgaard SK, Löfstedt H, Andersson K et al. Upper-airway inflammation in relation to dust spiked with aldehydes or glucan. Scandinavian Journal of Work, Environment & Health. 2006 Oct;32(5):374-82. doi: 10.5271/sjweh.1033
Bonefeld-Jørgensen EC, Long M, Krüger T, Hjelmborg PS, Reinert TS, Andersen BS et al.. Xenobiotic activity in serum of European and Inuit populations. 2006. Poster session presented at Gordon conference on "Environmental Endocrine Disrupters", Italy.
Bonefeld-Jørgensen EC, Hjelmborg PS, Reinert LS, Andersen BS, Lindh CH, Hagmar L et al. Xenoestrogenic activity in blood of European and Inuit populations. Environmental Health: A Global Access Science Source. 2006;5(1):1-12. doi: 10.1186/1476-069X-5-12
Krüger T, Hjelmborg PS, Goralczyk K, Pedersen HS, Shvets M, Rignell-Hydbom A et al.. Androgen-like activities in blood cleared for endogenous steroid hormones across European and Inuit populations. 2005. Poster session presented at Copenhagen Workshop on Environment, Reproductive Health and Fertility, København, Denmark.
Sumbayev VV, Bonefeld-Jørgensen E, Wind T, Andreasen P. A novel pesticide-induced conformational state of the oestrogen receptor ligand-binding domain, detected by conformation-specific peptide binding. FEBS Letters. 2005;579(2):541-8.
Hoffmann HJ, Iversen M, Sigsgaard T, Omland Ø, Takai H, Bonefeld-Jørgensen E et al. A single exposure to organic dust of non-naive non-exposed volunteers induces long-lasting symptoms of endotoxin tolerance. International Archives of Allergy and Immunology. 2005;138(2):121-6. doi: 10.1159/000088433
Guldager E, Bonefeld-Jørgensen E, Gross G, Larsen HL, Knudsen LE, Hertel O et al. Bedre miljø for børnene - et oplæg til handling. www.tekno.dk: Teknologirådet, 2005. 79 p.
JPB , Bonefeld-Jørgensen EC, Toft G, Giwercman A, Hagmar L, Spano M et al. Biopersistent organochlorines in diet and human fertility: Epidemiological studies of time to pregnancy and semen quality in Inuit and European populations: Afsluttende rapport til EU kommissionen for projektet INUENDO (Contract QLK4-CT-2001-00202. In Biopersistent organochlorines in diet and human fertility: Epidemiological studies of time to pregnancy and semen quality in Inuit and European populations. Brussels. 2005
Bonefeld-Jørgensen E, Grünfeld HT, Gjermandsen IM. Effect of pesticides on estrogen receptor transactivation in vitro: a comparison of stable transfected MVLN and transient transfected MCF-7 cells. Molecular and Cellular Endocrinology. 2005;244(1-2):20-30.
Bonefeld-Jørgensen EC, Long M, Hofmeister MV, Vinggaard AM. Endocrine disrupting potentials of Bisphenol A, Bisphenol A dimethacrylate, 4-n-Nonyl-phenol and 4-Octylphenol assessed in cell model systems for effects on the estrogen-, androgen-, aryl hydrocarbon-receptor and aromatase activity.. 2005. Poster session presented at EU-CREDO Conference in PRAG: Endocrine Disrupters, PRAG, Czech Republic.
Hjelmborg PS, Andersen BS, Sinnathamby T, Goralczyk K, Pedersen HS, Shvets M et al.. Estrogen-like activities in blood cleared for endogenous steroid hormones across European and Inuit populations. 2005. Poster session presented at 3rd Copenhagen Workshop on Environment, Reproductive Health and Fertility, Rigshospitalet - København, Denmark.
Toft G, Axmon A, Giwercman A, Thulstrup AM, Rignell-Hydbom A, Pedersen HS et al. Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study. Environ Health. 2005;4:26-26. doi: 10.1186/1476-069X-4-26
Nellemann C, Dalgaard M, Holst B, Bonefeld-Jørgensen E, Vinggaard AM. Gene expression changes in rat prostate after activation or blocking of the androgen and estrogen receptor. Molecular and Cellular Endocrinology. 2005;237(1-2):25-35. doi: 10.1016/j.mce.2005.04.002
Ghisari M, Bonefeld-Jørgensen E. Impact of environmental chemicals on the thyroid hormone function in pituitary rat GH3 cells. Molecular and Cellular Endocrinology. 2005;244(1-2):31-41.
Jonsson BA, Rylander L, Lindh C, Rignell-Hydbom A, Giwercman A, Toft G et al. Inter-population variations in concentrations, determinants of and correlations between 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE): a cross-sectional study of 3161 men and women from Inuit and European populations. Environ Health. 2005;4(1):27.
Sigsgaard T, Bonefeld-Jørgensen EC, Hoffmann HJ, Bønløkke J, Krüger T. Microbial cell wall agents as an occupational hazard. Toxicology and Applied Pharmacology. 2005;207(2 Suppl):310-9. doi: 10.1016/j.taap.2004.12.031
Bodin L, Andersson K, Mølhave L, Bønløkke J, Kjærgaard SK, Sigsgaard T et al. Symptom reports from groups with different sensitivity of the mucous membranes in a climate chamber study. Indoor Air. 2005;15(suppl.11):7. doi: 10.1111/j.1600-0668.2005.00002.x
Mølhave L, Sigsgaard T, Kjærgaard SK, Juto JE, Andersson K, Stridh G et al. Changes in airway mucosal membranes after experimental exposure to dust containing glucan and volatile organic compounds: Vol. 3: Effects of dust exposure in climate chamber. Final Report to FORMAS. 2004. 146 p.
Theander Grünfeld H, Bonefeld-Jørgensen EC. Effect of in vitro estrogenic pesticides on human oestrogen receptor α and β mRNA levels. Toxicology Letters. 2004;151(3):467-480. doi: 10.1016/j.toxlet.2004.03.021
Hjelmborg PS, Bonefeld-Jørgensen EC. Extraction of xenoestrogens from human serum samples by solid phase extraction and removal of endogenous hormones by high-performance liquid chromatography for the determination of the total xenoestrogenic activity. 2004. Poster session presented at Hormones and the Genome: Basic research towards improvement of diagnostic and therapeutic medicine, Günzburg/Ulm, Germany.
Krüger T, Sigsgaard T, Bonefeld-Jørgensen EC. Ex vivo induction of cytokines by mould components in whole blood of atopic and non-atopic volunteers. Cytokine. 2004 Jan 21;25(2):73-84. doi: 10.1016/j.cyto.2003.10.001
Vinggaard AM, Bonefeld-Jørgensen EC, Andersen HR, Hass U, Nellemann CL, Kjærstad MB et al. In vitro og in vivo hormonforstyrrende effekter af kombinationer af aktive komponenter af pesticider: Report to the Danish Environmental Agency. 2004. (Bekæmpelsesmiddelforskning fra Miljøstyrelsen, Vol. 88).
Bønløkke J, Thomassen M, Viskum S, Omland Ø, Bonefeld-Jørgensen EC, Sigsgaard T. Respiratory symptoms and ex vivo cytokine release are associated in workers processing herring. International Archives of Occupational and Environmental Health. 2004;77(2):136-141.
Bonefeld-Jørgensen EC. The Human Health Programme in Greenland, a review. Science of the Total Environment. 2004 Mar 23;331(1-3):215-231. doi: 10.1016/j.scitotenv.2004.03.030
Sigsgaard T, Mølhave L, Kjærgaard SK, Bønløkke J, Bonefeld-Jørgensen E, Juto JE et al. Cytokine release from mucosal membranes after experimentel exposures to organic dust - DAMOS. In Center for Miljø og Luftveje: Final report. København: Det Nationale Forskningscenter for Arbejdsmiljø. 2003. p. 15-25
Long M, Laier P, Vinggaard AM, Lynggaard J, Bonefeld-Jørgensen EC. Effect of currently used pesticides in the AhR-CALUX assay: comparison between the human TV101L and the rat H4IIE cell line. 2003. Poster session presented at Nordic Conference of the Nordic Societies of Toxicology and Environmental Mutagenesis, Bornholm, Denmark.
Long M, Laier P, Vinggaard AM, Raun Andersen H, Lynggaard J, Bonefeld-Jørgensen EC. Effects of currently used pesticides in the AhR-CALUX assay: comparison between the human TV101L and the rat H4IIE cell line. Toxicology. 2003;194(1-2):77-93. doi: 10.1016/j.tox.2003.08.001
Sigsgaard T, Bælum J, Bonefeld-Jørgensen EC, Hoffmann HJ, Mølhave L, Takai H et al. Mikroorganismer og deres biologiske aktive komponenter. Miljøforskning : Nyhedsbrev. 2003;55:15-25.
Mølhave L, Sigsgaard T, Kjærgaard SK, Juto JE, Andersson K, Bodin L et al. Projekt DAMOS: Slimhindeeffekter efter eksperimentel udsættelse for støv tilsat glukan eller aldehyd. Miljø og sundhed. 2003;(Suppl. 2):30-32.
Deutch B, Pedersen HS, Bonefeld-Jørgensen EC, Hansen JC. Smoking as a Determinant of High Organochlorine Levels in Greenland. Archives of Environmental Health. 2003;58(1):30-36.
Bonefeld-Jørgensen EC, Deutch B, (ed.), Hansen JC, (ed.). The Human Health Effects Biomarkers Program: Chapter 7. In AMAP Greenland and Faroe Islands 1997-2001: Vol 1: Human Health. Dancea Danish Cooperation for Environment in the Arctic. Ministry of Environment. Copenhagen. 2003. p. 213-230
Bonefeld-Jørgensen EC, Ayotte P. Toxicological Properties of Persistent Organic Pollutants and Related Health Effects of Concern for the Arctic Populations. In AMAP Assessment 2002: Human Health in the Arctic. Oslo: Arctic Monitoring and Assessment Programme (AMAP). 2003. p. 57-74
Vinggaard AM, Nellemann C, Dalgaard M, Bonefeld-Jørgensen EC, Raun Andersen H. Antiandrogenic effects in vitro and in vivo of the fungicide prochloraz. Toxicological Sciences. 2002 Oct;69(2):344-353.
Long M, Bonefeld-Jørgensen EC. Application of CALUX bioassay for determination of dioxin-like activity in human serum samples. 2002. Poster session presented at 2nd AMAP international symposium on environmental pollution of the Arctic, Rovaniemi, Finland.
Andersen HR, Vinggaard AM, Rasmussen TH, Gjermandsen IM, Bonefeld-Jørgensen EC. Effects of currently used pesticides in assays for estrogenicity, androgenicity and aromatase activity in vitro. Toxicol. Appl. Pharmacol. 2002;179(1):1-12.
Rattenborg T, Gjermandsen I, Bonefeld-Jørgensen EC. Inhibition of E2-induced expression of BRCA1 by persistent organochlorines. Breast Cancer Research. 2002;4(6):R12. doi: 10.1186/bcr461
Long M, Bonefeld-Jørgensen EC. Measurement of the actual concerted action of biomarkers: Estrogenic dioxin-like activities in human samples as effect markers of organochlorine bioaccumulation. 2002. Poster session presented at 2nd AMAP international symposium on environmental pollution of the Arctic, Rovaniemi, Finland.
Bonefeld-Jørgensen EC, Andersen HR, Rasmussen TH, Vinggaard AM. Effect of highly bioaccumulated polychlorinated biphenyl congeners on estrogen and androgen receptor activity. Toxicology. 2001;158(3):141-53. doi: 10.1016/S0300-483X(00)00368-1
Bonefeld-Jørgensen EC, Møller SM, Hansen JC. Modulation of atherosclerotic risk factors by seal oil: a preliminary assessment. Int. J. Circumpolar Health. 2001;60(1):25-33.
Sigsgaard T, Bonefeld-Jørgensen EC, Kjaergaard SK, Mamas S, Pedersen OF. Cytokine release from the nasal mucosa and whole blood after experimental exposures to organic dusts. European Respiratory Journal. 2000;16(1):140-5.
Deutch B, Bonefeld-Jørgensen EC, Hansen JC. Menstrual discomfort in Danish women reduced by dietary supplements of omega-3 PUFA and B12 (fish oil or seal oil capsules). Nutrition Research. 2000;20(5):621-631.
Bonefeld-Jørgensen EC. Molecular aspects of POPs toxicity: Workshop on Persistent Organic Pollutants (POPs) in the Arctic: Human Health and Environmental Concern. Abstract 6. Proceeding of the workshop, Rovaniemi, 18-20 January 2000. 2000;1-4.
Deutch B, Bonefeld-Jørgensen EC, Hansen JC. N-3 PUFA from fish or seal oil reduce atherogenic risk indicators in Danish women. Nutrition Research. 2000;20(8):1065-1077.
Vinggaard AM, Bonefeld-Jørgensen EC. PCB138, but not PCB153 and PCB180, acts as a weak antiandrogen in vitro. Organohalogen Compounds. 2000;49:334-337.
Andersen HR, Andersson AM, Arnold SF, Autrup H, Barfoed M, Beresford NA et al. Comparison of Short-Term Estrogenicity Tests for Identification of Hormone-Disrupting Chemicals. Environmental Health Perspectives. 1999;107(Suppl 1):89-108. doi: 10.2307/3434476
Vinggaard AM, Bonefeld-Jørgensen EC, Larsen JC. Rapid and Sensitive Reporter Gene Assays for Detection of Antiandrogenic and Estrogenic Effects of Environmental Chemicals. Toxicology and Applied Pharmacology. 1999 Mar 1;155(2):150-160. doi: 10.1006/taap.1998.8598
Sigsgaard T, van der Maarl E, Bak N, Bonefeld-Jørgensen EC, Omland Ø, Doekes G. The effect of smoking on cytokine release after exposure to organic dust components in a whole blood assay. Proceedings of the XXIIIrd Cotton Dust Conference. 1999;197-200.
Bonefeld-Jørgensen EC, Autrup H, Hansen JC. Effect of Toxaphene on estrogen receptor functions in human breast cancer cells. Carcinogenesis. 1997;18:1651-1654.
Autrup H, Bonefeld-Jørgensen EC, Jensen O. Aflatoxin B1 induced lacI mutation in liver and kidney of transgenic mice C57BL/6N: effect of phorone. Mutagenesis. 1996;11:69-73.
Bonefeld-Jørgensen EC, Autrup H. Autoregulation of the human CYP1A1 gene promotor activity in HepG2 and MCF-7 cells. Carcinogenesis. 1996;17:435-441.
Bonefeld-Jørgensen EC, Autrup H. Effect of a negative regulatory element (NRE) on the human CYP1A1 gene expression in breast carcinoma MCF-7 and hepatoma HepG2 cells. FEBS Letters. 1995;365:101-107.
Pedersen K, Lovmand S, Bonefeld-Jørgensen EC, Pedersen FS, Jørgensen P. Efficient replication and expression of murine leukemia virus with major deletions in the enhancer region of U3. Virology. 1992;187(2):821-4.
Pedersen K, Lovmand S, Bonefeld-Jørgensen EC, Pedersen FS, Jørgensen P. Efficient replication and expression of murine leukemia virus with major deletions in the enhancer region of U3. Virology. 1992;187(2):821-4.
Bonefeld-Jørgensen EC, Pedersen FS, Jørgensen P. Matrix protein of Akv murine leukemia virus: genetic mapping of regions essential for particle formation. Journal of Virology. 1992;66(7):4479-87.
Bonefeld-Jørgensen EC, Kjeldgaard NO, Pedersen FS, Jørgensen P. A nucleotide substitution in the gag N terminus of the endogenous ecotropic DBA/2 virus prevents Pr65gag myristylation and virus replication. Journal of Virology. 1988;62(9):3217-23.
Gesser H, Bonefeld-Jørgensen EC. Effect of vanadate and of removal of extracellular Ca2+ and Na+ on tension development and 45Ca efflux in rat and frog myocardium:  Comparative biochemistry and physiology. 1983;76(1):199-202.
Gesser H, Bonefeld-Jørgensen EC. pHj, contractility and Ca-balance under hypercapnic acidosis in the myocardium of different vertebrate species. Journal of Experimental Biology. 1982;96:405-12.

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Revised 19.01.2023
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Maria Wielsøe