Centre for Arctic Health and Molecular Epidemiology

 Department of public health Centre for Arctic Health Publications

Publications

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Ghisari M, Bonefeld-Jørgensen EC. Effects of plasticizers and their mixtures on estrogen Receptor and thyroid hormone functions. Toxicology Letters. 2009;189(1):67-77. doi: 10.1016/j.toxlet.2009.05.004
Ghisari M, Bonefeld-Jørgensen EC. Effects of plasticizers and phenols on estrogen and thyroid hormone functions. Toxicology Letters. 2008 Oct 5;180(Supplement):S104. V32. doi: 10.1016/j.toxlet.2008.06.423
Krüger T, Cao Y, Kjærgaard SK, Knudsen LE, Bonefeld-Jørgensen EC. Effects of Phthalates on the Human Corneal Endothelial Cell Line B4G12. International Journal of Toxicology. 2012 Aug;31(4):364-71. doi: 10.1177/1091581812449660
Long M, Ghisari M, Bonefeld-Jørgensen EC. Effects of perfluoroalkyl acids on the function of the thyroid hormone and the aryl hydrocarbon receptor. Environmental Science and Pollution Research. 2013 Mar 29;20(11):8045–8056. doi: 10.1007/s11356-013-1628-7
Taxvig C, Engell-Kofoed AE, Sonne-Hansen K, Bonefeld-Jørgensen EC, Vinggaard AM, Lykkesfelt AE et al. Effects of nutrition relevant mixtures of phytoestrogens on steroidogenesis, aromatase, estrogen, and androgen activity. Nutrition and Cancer. 2010;62(1):122-131.
Ghisari M, Kjeldsen L, Bonefeld-Jørgensen EC. Effects of currently used pesticides on estrogen and thyroid hormone function in vitro. Toxicology Letters. 2010 Jul 17;196(1):324. doi: 10.1016/j.toxlet.2010.03.1022
Long M, Laier P, Vinggaard AM, Raun Andersen H, Lynggaard J, Bonefeld-Jørgensen EC. Effects of currently used pesticides in the AhR-CALUX assay: comparison between the human TV101L and the rat H4IIE cell line. Toxicology. 2003;194(1-2):77-93. doi: 10.1016/j.tox.2003.08.001
Ghisari M, Long M, Bonefeld-Jorgensen EC. Effects of currently used pesticides in Denmark on the function of the thyroid hormone and the aryl hydrocarbon receptor. Toxicology Letters. 2014 Sept 10;229(Supplement):S63. P.1-71. doi: 10.1016/j.toxlet.2014.06.251
Andersen HR, Vinggaard AM, Rasmussen TH, Gjermandsen IM, Bonefeld-Jørgensen EC. Effects of currently used pesticides in assays for estrogenicity, androgenicity and aromatase activity in vitro. Toxicol. Appl. Pharmacol. 2002;179(1):1-12.
Ghisari M, Long M, Tabbo A, Bonefeld-Jørgensen EC. Effects of currently used pesticides and their mixtures on the function of thyroid hormone and aryl hydrocarbon receptor in cell culture. Toxicology and Applied Pharmacology. 2015 May 1;284(3):292-303. doi: 10.1016/j.taap.2015.02.004
Gesser H, Bonefeld-Jørgensen EC. Effect of vanadate and of removal of extracellular Ca2+ and Na+ on tension development and 45Ca efflux in rat and frog myocardium: Comparative Biochemistry and Physiology (historisk, uspecificeret). 1983;76(1):199-202.
Bonefeld-Jørgensen EC, Autrup H, Hansen JC. Effect of Toxaphene on estrogen receptor functions in human breast cancer cells. Carcinogenesis. 1997;18:1651-1654.
Bonefeld-Jørgensen E, Grünfeld HT, Gjermandsen IM. Effect of pesticides on estrogen receptor transactivation in vitro: a comparison of stable transfected MVLN and transient transfected MCF-7 cells. Molecular and Cellular Endocrinology. 2005;244(1-2):20-30.
Theander Grünfeld H, Bonefeld-Jørgensen EC. Effect of in vitro estrogenic pesticides on human oestrogen receptor α and β mRNA levels. Toxicology Letters. 2004;151(3):467-480. doi: 10.1016/j.toxlet.2004.03.021
Bonefeld-Jørgensen EC, Andersen HR, Rasmussen TH, Vinggaard AM. Effect of highly bioaccumulated polychlorinated biphenyl congeners on estrogen and androgen receptor activity. Toxicology. 2001;158(3):141-53. doi: 10.1016/S0300-483X(00)00368-1
Ghisari M. Effect of Environmental Chemicals on Thyroid and Estrogen Hormone Action in vitro and ex vivo. Aarhus Universitet, 2009.
Long M, Laier P, Vinggaard AM, Lynggaard J, Bonefeld-Jørgensen EC. Effect of currently used pesticides in the AhR-CALUX assay: comparison between the human TV101L and the rat H4IIE cell line. 2003. Poster session presented at Nordic Conference of the Nordic Societies of Toxicology and Environmental Mutagenesis, Bornholm, Denmark.
Bonefeld-Jørgensen EC, Autrup H. Effect of a negative regulatory element (NRE) on the human CYP1A1 gene expression in breast carcinoma MCF-7 and hepatoma HepG2 cells. FEBS Letters. 1995;365:101-107.
Bonefeld-Jørgensen EC, Long M. Early-life environmental influences on growth. In Xia Y, editor, Early-life environmental exposure and disease: facts and perspectives. Singapore: Springer Nature. 2020. p. 113-140 doi: 10.1007/978-981-15-3797-4
Wielsøe M, Tarantini L, Bollati V, Long M, Bonefeld-Jørgensen EC. DNA methylation level in blood and relations to breast cancer, risk factors and environmental exposure in Greenlandic Inuit women. Basic & Clinical Pharmacology & Toxicology. 2020 Oct 1;127(4):338-350. doi: 10.1111/bcpt.13424
Tairova Z, Strand J, Dahllöf I, Bonefeld-Jørgensen EC. Distruption of vitamins and CYP systems and embryo development in brood-bearing marine organisms. 2011. Poster session presented at Primo 16 - Pollutant Responses in Marine organisms, Long Beach, California, United States.
Long M, Bonefeld-Jørgensen EC. Dioxin-like potential of environmental compounds. Miljø og Sundhed. 2011 Dec;17(3):18-38.
Long M, Bonefeld-Jørgensen EC. Dioxin-like activity of environmental compounds in human blood and environmental samples. Chemosphere. 2012 Nov;89(8):919-928. doi: 10.1016/j.chemosphere.2012.06.055
Bonefeld-Jørgensen EC, Long M. Dioxin-like activity in the blood of Greenlandic Inuit and Danish women: A pilot study. International Journal of Circumpolar Health. 2010;69(2):181-194. doi: 10.3402/ijch.v69i2.17434
Long M, Wielsøe M, Bonefeld-Jørgensen EC. Dioxin-like activity in serum of Danish and Greenlandic Inuit pregnant women and fetal growth indices. Toxicology Letters. 2021 Sept;350(Supplement 1):S145-S146. P12-01. doi: 10.1016/S0378-4274(21)00585-3
Long M, Wielsøe M, Bonefeld-Jørgensen EC. Dioxin-like Activity in Pregnant Women and Indices of Fetal Growth: The ACCEPT Birth Cohort. Toxics. 2022 Jan;10(1):26. doi: 10.3390/toxics10010026
Long M, Bonefeld-Jørgensen EC. Dioxin-like activity in environmental and human samples from Greenland and Denmark. Chemosphere. 2012 Nov;89(8):919-28.
Bonefeld-Jørgensen EC, Long M. Dioxin-like activity in blood of Greenlandic Inuit and danish Women. International Journal of Circumpolar Health. 2010;69(2):181-194.
Long M, Andersen BS, Lindh CH, Hagmar L, Giwercman A, Manicardi GC et al. Dioxin-like activities in serum across European and Inuit populations. Environmental Health: A Global Access Science Source. 2006;(5):14-26.
Long M, Andersen BS, Lindh CH, Hagmar L, Giwercman A, Manicardi GC et al.. Dioxin-like activities in serum across European and Inuit population. 2006. Poster session presented at Dioxin 2006, Oslo, Norway.
Long M, Sonne C, Dietz R, Bossi R, Jørgensen N, Olsen TI et al. Diet, lifestyle and contaminants in three east Greenland Inuit municipalities. Chemosphere. 2023 Dec;344:140368. doi: 10.1016/j.chemosphere.2023.140368
Wielsøe M, Berthelsen D, Mulvad G, Isidor S, Long M, Bonefeld-Jørgensen EC. Dietary habits among men and women in West Greenland: follow-up on the ACCEPT birth cohort. BMC Public Health. 2021 Dec;21(1):1426. doi: 10.1186/s12889-021-11359-7
Fleischer I, Schaebel LK, Albertsen N, Sorensen VN, Andersen S. Diagnosis of osteoporosis in rural Arctic Greenland: a clinical case using plain chest radiography for secondary prevention and consideration of tools for primary prevention in remote areas. Rural and Remote Health. 2017;17(1):3910. 3910. doi: 10.22605/rrh3910
Hoffmann L, Linaa MB, Ehmsen ML, Jensen MF, Eckholdt S, Larsen C et al. Development of a treatment planning protocol for the multi-centre reirradiation CURE Lung trial. Radiotherapy and Oncology. 2026 Jan;214:111293. doi: 10.1016/j.radonc.2025.111293
Bjerregaard-Olesen C, Bonefeld-Jørgensen EC. Development of a method to combine the extraction of both PFCs and legacy-POPs from human serum.. 2011. Poster session presented at 3rd international workshop on per- and polyfluorinated substances, Amsterdam, Netherlands.
Bjerregaard-Olesen C, Bach CC, Long M, Ghisari M, Bech BH, Nohr EA et al. Determinants of serum levels of perfluorinated alkyl acids in Danish pregnant women. International Journal of Hygiene and Environmental Health. 2016 Nov 1;219(8):867-875. doi: 10.1016/j.ijheh.2016.07.008
Mølhave L, Sigsgaard T, Kjærgaard SK, Juto JE, Andersson K, Stridh G et al. DAMOS: Changes in airway mucosal membranes after experimental exposures to dust containing glucan and volatile organic compounds. Vol 2. Exposure characterization. Research reports from the Air Pollution Unit. Aarhus University, 2007. 43 p.
Sigsgaard T, Bonefeld-Jørgensen EC, Kjaergaard SK, Mamas S, Pedersen OF. Cytokine release from the nasal mucosa and whole blood after experimental exposures to organic dusts. European Respiratory Journal. 2000;16(1):140-5.
Sigsgaard T, Mølhave L, Kjærgaard SK, Bønløkke J, Bonefeld-Jørgensen E, Juto JE et al. Cytokine release from mucosal membranes after experimentel exposures to organic dust - DAMOS. In Center for Miljø og Luftveje: Final report. København: Det Nationale Forskningscenter for Arbejdsmiljø. 2003. p. 15-25
Kjeldsen LS, Ghisari M, Bonefeld-Jørgensen EC. Currently used pesticides and their mixtures affect the function of sex hormone receptors and aromatase enzyme activity. Toxicology and Applied Pharmacology. 2013;272:453-464.
Lohmann R, Abass K, Bonefeld-Jørgensen EC, Bossi R, Dietz R, Ferguson S et al. Cross-cutting studies of per- and polyfluorinated alkyl substances (PFAS) in Arctic wildlife and humans. Science of the Total Environment. 2024 Dec 1;954:176274. doi: 10.1016/j.scitotenv.2024.176274
Thomsen M, Knudsen L, Vorkamp K, Frederiksen M, Bach HK, Bonefeld-Jørgensen EC et al. Conceptual framework for a Danish human biomonitoring program. Environmental Health: A Global Access Science Source. 2008;7(S1):S1-S3. doi: 10.1186/1476-069X-7-S1-S3
Andersen HR, Andersson AM, Arnold SF, Autrup H, Barfoed M, Beresford NA et al. Comparison of Short-Term Estrogenicity Tests for Identification of Hormone-Disrupting Chemicals. Environmental Health Perspectives. 1999;107(Suppl 1):89-108. doi: 10.2307/3434476
Fredslund SO, Buus NH, Skjold C, Laugesen E, Jensen AB, Laursen BE. Changes in vascular function during breast cancer treatment. British Journal of Clinical Pharmacology. 2021 Nov;87(11):4230-4240. Epub 2021 Mar 26. doi: 10.1111/bcp.14837
Mølhave L, Sigsgaard T, Kjærgaard SK, Juto JE, Andersson K, Stridh G et al. Changes in airway mucosal membranes after experimental exposure to dust containing glucan and volatile organic compounds: Vol. 3: Effects of dust exposure in climate chamber. Final Report to FORMAS. 2004. 146 p.
Mølhave L, Sigsgaard T, Kjærgaard SK, Juto JE, Andersson K, Stridh G et al. Changes in airway mucosal membranes after experimental exposures to dust containing glucan and volatile organic compounds. Exposure characterization. Final summary report to Formas. Aarhus: The Air Pollution Unit, Dept. Occupational and Environmental Medicine, The University of Aarhus., 2006. 10 p.
Hjelmborg PS, Andreassen TK, Bonefeld-Jørgensen EC. Cellular uptake of lipoproteins and Persistent Organic Compounds - An update and new data. Environmental Research. 2008;108(2):192-198. doi: 10.1016/j.envres.2008.07.019
Lauby-Secretan B, Loomis D, Grosse Y, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L et al. Carcinogenicity of polychlorinated biphenyls and polybrominated biphenyls. Lancet Oncology. 2013 Apr;14(4):287-8. doi: 10.1016/S1470-2045(13)70104-9
Bonefeld-Jørgensen EC, Long M, Fredslund SO, Bossi R, Olsen J. Breast cancer risk after exposure to perfluorinated compounds in Danish women: a case-control study nested in the Danish National Birth Cohort. Cancer Causes & Control. 2014 Aug 23;25(11):1439-1448. doi: 10.1007/s10552-014-0446-7
Fredslund SO, Bonefeld-Jørgensen EC. Breast cancer in the Arctic - changes over the past decades. International Journal of Circumpolar Health. 2012 Aug 16;71:19155. doi: 10.3402/ijch.v71i0.19155
JPB , Bonefeld-Jørgensen EC, Toft G, Giwercman A, Hagmar L, Spano M et al. Biopersistent organochlorines in diet and human fertility: Epidemiological studies of time to pregnancy and semen quality in Inuit and European populations: Afsluttende rapport til EU kommissionen for projektet INUENDO (Contract QLK4-CT-2001-00202. In Biopersistent organochlorines in diet and human fertility: Epidemiological studies of time to pregnancy and semen quality in Inuit and European populations. Brussels. 2005
Bonefeld-Jørgensen EC. Biomonitoring in Greenland: human biomarkers of exposure and effects - a short review. Rural and Remote Health. 2010;10(2):1362.
Bonefeld-Jørgensen EC, Ghisari M, Wielsøe M, Bjerregaard-Olesen C, Kjeldsen LS, Long M. Biomonitoring and hormone-disrupting effect biomarkers of persistent organic pollutants in vitro and ex vivo. Basic & Clinical Pharmacology & Toxicology. 2014 Jul;115(1):118-28. doi: 10.1111/bcpt.12263
Bonefeld-Jørgensen EC. Biomonitering i Grønland. Humane biomarkører - eksponering og effekter. Miljø og sundhed. 2009;(1):57.
Krüger T, Ghisari M, Long M, Bonefeld-Jørgensen EC. Biomarkers used in Environmental Health with focus on Endocrine Disrupters. In Friis RH, editor, The Praeger Handbook of Environmental Health. ABC-Clio. 2012. p. 259-280
Krüger T, Ghisari M, Long M, Bonefeld-Jørgensen EC. Biomarkers used in Environmental Health, with a Focus on Endocrine Disrupters. In Friis RH, editor, The Praeger Handbook of Environmental Health: Volume 1: Foundations of the Field, Volume 2: Agents of Disease, Volume 3: Water, Air, and Solid Waste, Volume 4: Current Issues and Emerging Debates. Vol. 1. Bloomsbury Publishing plc. 2012
Ghisari M, Krüger T, Long M, Bonefeld-Jørgensen EC. Biomarkers of Effects on Hormone Function. In Knudsen L, Merlo DF, editors, Biomarkers and Human Biomonitoring: Selected Biomarkers of Current Interest. Vol. 2. Royal Society of Chemistry. 2012. p. 142-159 doi: 10.1039/9781849733540
Guldager E, Bonefeld-Jørgensen E, Gross G, Larsen HL, Knudsen LE, Hertel O et al. Bedre miljø for børnene - et oplæg til handling. www.tekno.dk: Teknologirådet, 2005. 79 p.
Bonefeld-Jørgensen EC, Autrup H. Autoregulation of the human CYP1A1 gene promotor activity in HepG2 and MCF-7 cells. Carcinogenesis. 1996;17:435-441.
Long M, Ghisari M, Kjeldsen LS, Wielsøe M, Nørgaard-Pedersen B, Erik lykke M et al. Autism spectrum disorders, endocrine disrupting compounds and heavy metals in the amniotic fluid: A case-control study. Molecular Autism. 2019 Jan 9;10(1):1. 1. doi: 10.1186/s13229-018-0253-1
Liew Z, Ritz B, von Ehrenstein OS, Bech BH, Nohr EA, Fei C et al. Attention deficit/hyperactivity disorder and childhood autism in association with prenatal exposure to perfluoroalkyl substances: a nested case-control study in the Danish National Birth Cohort. Environmental Health Perspectives. 2015 Apr;123(4):367-73. doi: 10.1289/ehp.1408412
Christiansen CH, Pedersen ML, Bonefeld-Jørgensen EC, Nielsen MH. Asthma in Greenland - development and evaluation of the asthma symptom score. International journal of circumpolar health. 2025 Jul 28;84(1):2540684. doi: 10.1080/22423982.2025.2540684
Olesen CB, Bach CC, Long M, Wielsøe M, Bech BH, Henriksen TB et al. Associations of fetal growth outcomes with measures of the combined xenoestrogenic activity of maternal serum perfluorinated alkyl acids in Danish pregnant women. Environmental Health Perspectives. 2019 Jan 24;127(1):17006. doi: 10.1289/EHP1884
Elzanaty S, Rignell-Hydbom A, Jönsson BAG, Pedersen HS, Ludwicki JK, Shevets M et al. Association between exposure to persistent organohalogen pollutants and epididymal and accessory sex gland function: Multicentre study in Inuit and European populations. Reproductive Toxicology. 2006;22(4):765-773. doi: 10.1016/j.reprotox.2006.07.005
Sonne C, Desforges JP, Gustavson K, Bossi R, Bonefeld-Jørgensen EC, Long M et al. Assessment of exposure to perfluorinated industrial substances and risk of immune suppression in Greenland and its global context: a mixed-methods study. The Lancet. Planetary Health. 2023 Jul;7(7):e570-e579. doi: 10.1016/S2542-5196(23)00106-7
Rodríguez-Carrillo A, Rosenmai AK, Mustieles V, Couderq S, Fini JB, Vela-Soria F et al. Assessment of chemical mixtures using biomarkers of combined biological activity: A screening study in human placentas. Reproductive toxicology (Elmsford, N.Y.). 2021 Mar;100:143-154. Epub 2021 Jan 11. doi: 10.1016/j.reprotox.2021.01.002
Hoffmann HJ, Iversen M, Sigsgaard T, Omland Ø, Takai H, Bonefeld-Jørgensen E et al. A single exposure to organic dust of non-naive non-exposed volunteers induces long-lasting symptoms of endotoxin tolerance. International Archives of Allergy and Immunology. 2005;138(2):121-6. doi: 10.1159/000088433
Ma D, Qunhui Xie H, Zhang W, Xue Q, Liu X, Xu L et al. Aryl hydrocarbon receptor activity of polyhalogenated carbazoles and the molecular mechanism. Science of the Total Environment. 2019 Oct 15;687:516-526. doi: 10.1016/j.scitotenv.2019.05.406
Long M, Bonefeld-Jørgensen EC. Application of CALUX bioassay for determination of dioxin-like activity in human serum samples. 2002. Poster session presented at 2nd AMAP international symposium on environmental pollution of the Arctic, Rovaniemi, Finland.
Bajard L, Adamovsky O, Audouze K, Baken K, Barouki R, Beltman JB et al. Application of AOPs to assist regulatory assessment of chemical risks - Case studies, needs and recommendations. Environmental Research. 2023 Jan 15;217:114650. doi: 10.1016/j.envres.2022.114650
Bonefeld-Jørgensen EC, Kjeldgaard NO, Pedersen FS, Jørgensen P. A nucleotide substitution in the gag N terminus of the endogenous ecotropic DBA/2 virus prevents Pr65gag myristylation and virus replication. Journal of Virology. 1988;62(9):3217-23.
Vinggaard AM, Nellemann C, Dalgaard M, Bonefeld-Jørgensen EC, Raun Andersen H. Antiandrogenic effects in vitro and in vivo of the fungicide prochloraz. Toxicological Sciences. 2002 Oct;69(2):344-353.
Kok Grouleff M, Wielsøe M, Berthelsen D, Mulvad G, Isidor S, Long M et al. Anthropometric measures and blood pressure of Greenlandic preschool children. International Journal of Circumpolar Health. 2021 Dec;80(1):1954382. doi: 10.1080/22423982.2021.1954382
Sumbayev VV, Bonefeld-Jørgensen E, Wind T, Andreasen P. A novel pesticide-induced conformational state of the oestrogen receptor ligand-binding domain, detected by conformation-specific peptide binding. FEBS Letters. 2005;579(2):541-8.
Giwercman A, Rylander L, Rignell-Hydbom A, Jönsson BAG, Pedersen HS, Ludwicki JK et al. Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics. Pharmacogenetics and Genomics. 2007 Jun;17(6):391-401. doi: 10.1097/01.fpc.0000236329.26551.78
Krüger T, Hjelmborg PS, Goralczyk K, Pedersen HS, Shvets M, Rignell-Hydbom A et al.. Androgen-like activities in blood cleared for endogenous steroid hormones across European and Inuit populations. 2005. Poster session presented at Copenhagen Workshop on Environment, Reproductive Health and Fertility, København, Denmark.
Amadid H, Rønn PF, Bekker-Nielsen Dunbar M, Knudsen JS, Carstensen B, Persson F et al. A large remaining potential in lipid-lowering drug treatment in the type 2 diabetes population: A Danish nationwide cohort study. Diabetes, Obesity and Metabolism. 2021 Oct;23(10):2354-2363. doi: 10.1111/dom.14478
Long M, Deutch B, Bonefeld-Jørgensen EC. AhR transcription serum activity of Inuit´s across Greenlandic districts. Environmental Health: A Global Access Science Source. 2007;6(1).
Long M, Deutch B, Bonefeld-Jorgensen EC. AhR transcriptional activity in serum of Inuits across Greenlandic districts. Environmental Health: A Global Access Science Source. 2007 Oct 23;6:32. doi: 10.1186/1476-069X-6-32
Autrup H, Bonefeld-Jørgensen EC, Jensen O. Aflatoxin B1 induced lacI mutation in liver and kidney of transgenic mice C57BL/6N: effect of phorone. Mutagenesis. 1996;11:69-73.
Bjerregaard-Olesen C, Ghisari M, Bonefeld-Jørgensen EC. Activation of the estrogen receptor by human serum extracts containing mixtures of perfluorinated alkyl acids from pregnant women. Environmental Research. 2016 Nov;151:71-79. doi: 10.1016/j.envres.2016.07.001
Rønn PF, Andersen GS, Lauritzen T, Christensen DL, Aadahl M, Carstensen B et al. Abdominal visceral and subcutaneous adipose tissue and associations with cardiometabolic risk in Inuit, Africans and Europeans: a cross-sectional study. BMJ Open. 2020 Aug;10(9):e038071. doi: 10.1136/bmjopen-2020-038071

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Revised 19.01.2023
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Maria Wielsøe